Actin-Monomer-Binding Proteins by Pekka Lappalainen

By Pekka Lappalainen

The actin cytoskeleton performs a principal position in lots of mobile approaches together with phone motility, cytokinesis, endocytosis and phagocytosis. The constitution and dynamics of the actin cytoskeleton is regulated via a number of proteins that engage with monomeric and/or filamentous actin. Actin monomer binding proteins presents a entire view on actin monomer-binding proteins and the mechanisms in which they give a contribution to actin dynamics and numerous actin-dependent mobile approaches. This new name includes chapters that describe the elemental mechanisms of actin dynamics in addition to the structural ideas through which quite a few actin-binding proteins have interaction with actin.

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Weed SA, Karginov AV, Schafer DA et al. Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex. J Cell Biol 2000; 151(l):29-40. 122. Weaver AM, Karginov AV, Kinley A W et al. Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Curr Biol 2001; ll(5):370-374. 123. Uruno T, Liu J, Zhang P et al. Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat Cell Biol 2001; 3(3):259-266.

Hawkins M, Pope B, Maciver SK et al. H u m a n actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments. Biochemistry 1993; 32(38):9985-9993. 28. Hayden SM, Miller PS, Brauweiler A et al. Analysis of the interactions of actin depolymerizing factor widi G- and F-aain. Biochemistry 1993; 32(38):9994-10004. 29. Bobkov AA, Muhlrad A, Pavlov DA et al. Cooperative effects of cofilin (ADF) on actin structure suggest allosteric mechanism of cofilin fiinction. J Mol Biol 2006; 356(2):325-334.

Abe H, Nagaoka R, Obinata T. Cytoplasmic localization and nuclear transport of cofiHn in cultured myotubes. Exp Cell Res 1993; 206(1):1-10. 22. McGough A, Pope B, Chiu W et al. Cofilin changes the twist of F-actin: Implications for actin filament dynamics and cellular fiinction. J Cell Biol 1997; 138(4):771-781. 23. Gallon VE, Orlova A, Lukoyanova N et al. Actin depolymerizing factor stabilizes an existing state of F-actin and can change the tilt of F-actin subunits. J Cell Biol 2001; 153(l):75-86.

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